Open Office is an open source which means that the source code is public, and it can be changed and customized by the public. Unlike Open Office, MS Office is not free. On the other hand, MS Office has many versions, such as, Professional, Home and Student. Open Office comes only in a single version which is free to download. When looking at popularity, MS Office is used more often than Open Office. Though both of the software offers the same functionality to the users, they have many differences between them. MS Office and Open Office are popular software that users prefer.